Rule-based Mamdani-type fuzzy modeling of skin permeability

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Rule-based Mamdani-type fuzzy modeling of skin permeability

Two Mamdani type fuzzy models (three inputs–one output and two inputs–one output) were developed to predict the permeability of compounds through human skin. The models were derived from multiple data sources including laboratory data, published data bases, published statistical models, and expert opinion. The inputs to the model include information about the compound (molecular weight and octo...

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The skin is a major exposure route for many potentially toxic chemicals. It is, therefore, important to be able to predict the permeability of compounds through skin under a variety of conditions. Available skin permeability databases are often limited in scope and not conducive to developing effective models. This sparseness and ambiguity of available data prompted the use of fuzzy set theory ...

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ژورنال

عنوان ژورنال: Applied Soft Computing

سال: 2008

ISSN: 1568-4946

DOI: 10.1016/j.asoc.2007.01.007